TPN ELECTROLYTES (multitple electrolyte additive) Contraindications | Pfizer Medical Information - US (2024)

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TPN ELECTROLYTES (multitple electrolyte additive) Contraindications | Pfizer Medical Information - US? ›

TPN Electrolytes (multiple electrolyte additive) is contraindicated in pathological conditions where additives of potassium, sodium, calcium, magnesium or chloride could be clinically deleterious, e.g., anuria, hyperkalemia, heart block or myocardial damage and severe edema due to cardiovascular, renal or hepatic ...

Another metabolic complication and major concern associated with TPN use is electrolyte imbalance. TPN administration can disturb the levels of electrolytes in the body, like calcium, sodium, magnesium, and potassium, which can lead to further complications, such as arrhythmias, neuromuscular dysfunction, and others.

Between 10 and 30 mEq of potassium (as phosphate) should be added per liter of TPN solution, to augment the 20 mEq of potassium provided by TPN Electrolytes. Between two and three liters of TPN solution with added TPN Electrolytes are usually administered daily to adults.

TPN requires water (30 to 40 mL/kg/day), energy (30 to 35 kcal/kg/day, depending on energy expenditure; up to 45 kcal/kg/day for critically ill patients), amino acids (1.0 to 2.0 g/kg/day, depending on the degree of catabolism), essential fatty acids, vitamins, and minerals (see table Basic Adult Daily Requirements for ...

TPN patients usually require 30 to 50 mEq of potassium per liter of TPN solution containing concentrated (20—25%) dextrose.

Patients with severe liver diseases may not tolerate TPN well. The liver plays a crucial role in processing nutrients from the bloodstream. TPN is contraindicated in patients with severe liver disorders because it can exacerbate liver dysfunction.

Hyperglycemia (high blood sugars) Hypoglycemia (low blood sugars) Infection.

Patients with good nutritional status in whom only short term TPN support is anticipated. Irreversibly decerebrate patients. Lack of specific therapeutic goal: TPN should NOT be used to prolong life if death is inevitable [6]. Severe cardiovascular instability or metabolic derangements.

A: This depends. Some patients are placed on TPN to supplement nutrients. These types of patients can take in food and drink orally. Other patients on TPN are unable to properly digest food through their GI tract and attempting to do so can cause complications like blockages or dehydration.

What happens when TPN is stopped abruptly? ›

DISCUSSION: Hypoglycemia does not occur after abrupt discontinuation of TPN. The same changes in counterregulatory hormones were seen whether discontinuation was tapered or abrupt. In stable patients, TPN solutions can be abruptly discontinued.

Even when you receive total parenteral nutrition, your formula will be tailored to you based on lab results. Parenteral nutrition is complete enough to replace mouth feeding for as long as necessary — even for life.

Electrolytes (Sodium, Potassium & Magnesium), bone profile (Calcium & Phosphate), infection markers (such as C Reactive Protein and white blood cells) and liver function tests should be taken at baseline, reviewed daily until stable and then at each planned follow up.

TPN Electrolytes (multiple electrolyte additive) helps to maintain normal cellular metabolism during TPN (total parenteral nutrition). Providing electrolytes in appropriate amounts prevents deficiency symptoms which otherwise would occur in their absence.

TPN correction: Increase the magnesium content of the TPN solution to a maximum of 12 mEq per liter. The total daily dosage of magnesium should not exceed 36 mEq. Decreased excretion due to renal disease.

Amiodarone, pentobarbital, phenobarbital, and rifampin were not compatible with the neonatal TPN solution and should not be coadministered via Y-site injection.

Extreme fatigue. A prolonged bout of diarrhea or vomiting. Signs of dehydration. Unexplained confusion, muscle cramps, numbness or tingling.

The signs and symptoms you may experience in fluid overload may include: Shortness of breath. High blood pressure. Swelling in the feet, ankles, or abdomen.

Medications that may predispose to the development of hyperkalemia include digoxin, potassium-sparing diuretics, non-steroidal anti-inflammatory drugs, ace-inhibitors or recent intravenous (IV) potassium, total parenteral nutrition, potassium penicillin or succinylcholine.